Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker RGD Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aβ1-42 CA1-injected rats. 30066400

2019

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. 29948724

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.210 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.230 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Therapeutic RGD Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats. 29568075

2018

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. 29257340

2018

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker RGD Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. 29174383

2018

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. 29126976

2018

Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Therapeutic RGD Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. 29126976

2018

Entrez Id: 4035
Gene Symbol: LRP1
LRP1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Therapeutic RGD Effect of Linguizhugan decoction on neuroinflammation and expression disorder of the amyloid β‑related transporters RAGE and LRP‑1 in a rat model of Alzheimer's disease. 29115637

2018

Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD We found that NP03 rescued key initiating components of AD pathology, including inactivating GSK-3β, reducing BACE1 expression and activity, and reducing amyloid levels. 28763060

2017

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Neuroprotective mechanism of 28553348

2017

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation. 28447730

2017

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. 28342971

2017

Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.260 Biomarker RGD Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. 28302704

2017

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Therapeutic RGD Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. 28269780

2017

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease. 28157092

2017

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway. 27893738

2016